Federico obtained a B.Sc. in Biology from the University of Padova and an M.Sc. in Neurobiology from Sapienza University of Rome. Prior to his doctoral studies, he worked as a Research Assistant at the DZNE in Tübingen, where he employed iPSC-derived models to investigate Parkinson’s disease mechanisms, focusing on LRRK2 and GBA1 mutations.  Federico joined the lab  at the Imagine Institute in September 2023, as a PhD student. He is interested in dissecting the early molecular events of Parkinson’s disease through a multi-modal approach. He utilizes single-cell and spatial transcriptomics in 3D midbrain organoids to map the microenvironmental drivers of selective neuronal vulnerability. In parallel, he employs iPSC-derived 2D monocultures to deconvolute cell-autonomous responses, integrating transcriptomics and metabolomics to link metabolic dysfunction to pathological gene expression